| Race Name | Date | Location | Winner | Laps Led |
| Firestone Grand Prix of St. Petersburg | Sunday, March 1 | Streets of St. Petersburg | Alex Palou | 59/100 |
| Good Ranchers 250 | Saturday, March 7 | Phoenix Raceway | Josef Newgarden | 8/250 |
| Java House Grand Prix of Arlington | Sunday, March 15 | Streets of Arlington | Kyle Kirkwood | 16/70 |
| Children’s of Alabama INDY Grand Prix | Sunday, March 29 | Barber Motorsports Park | Alex Palou | 79/90 |
| Acura Grand Prix of Long Beach | Sunday, April 19 | Streets of Long Beach | Alex Palou | 32/90 |
| Sonsio Grand Prix | Saturday, May 9 | Indianapolis Motor Speedway (road course) | Christian Lundgaard | 20/85 |
| 110th Running of the Indianapolis 500 | Sunday, May 24 | Indianapolis Motor Speedway (oval) | Felix Rosenqvist | 25/200 |
| Chevrolet Detroit Grand Prix | Sunday, May 31 | Streets of Detroit | Alex Palou | 71/100 |
| Bommarito Automotive Group 500 | Sunday, June 7 | World Wide Technology Raceway | Josef Newgarden | 53/260 |
| XPEL Grand Prix at Road America | Sunday, June 21 | Road America | Christian Lundgaard | 7/55 |
| The Honda Indy 200 At Mid-Ohio | Sunday, July 5 | Mid-Ohio Sports Car Course | Pato O’Ward | 45/90 |
| Borchetta Bourbon Music City Grand Prix | Sunday, July 19 | Nashville Superspeedway | Alex Palou | 97/225 |
| ONLYBULLS Grand Prix of Portland | Sunday, Aug. 9 | Portland International Raceway | Alex Palou | 60/110 |
| Ontario Honda Dealers Indy at Markham | Sunday, Aug. 16 | Streets of Markham | Marcus Ericsson | 21/90 |
| Freedom 250 | Sunday, Aug. 23 | Streets of Washington | | |
| Milwaukee Mile Race 1 | Saturday, Aug. 29 | Milwaukee Mile | | |
| Milwaukee Mile Race 2 | Sunday, Aug. 30 | Milwaukee Mile | | |
| WeatherTech Raceway Laguna Seca | Sunday, Sep. 6 | WeatherTech Raceway Laguna Seca | | |
